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CRPS (Complex Regional Pain Syndrome) AKA RSD (Reflex Sympathetic Dystrophy
Lecture by Dr.Pradeep Chopra (Rhode Island)
90% of our Central Nervous System (CNS) are Glia cells
Glia Cells are activated with RSD releasing an inflammatory reaction
During this inflammatory reaction there is a 24/7 barrage of pain signals
The CNS can not keep up and the pain cycle gets out of control
Central Sensitization occurs meaning the pain now processes normal stimulus as painful--localized treatment peripherally does not help
NMDA receptors activated in the CNS more responsive to pain signals
Also there is a decrease sensitivity to opiods (classic pain killers)
Glial Cells are activated in this process with NMDA Receptors acting like keyholes.
Drugs that block NMDA receptors include ketamine, and can decrease this abnormal pain response.
Glial cells are normally dormant
Active glial cells during RSD release cytokines, making nerves inflamed
Exercise helps decrease this inflam
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