Lessons
learned from the treatment of Complex Regional Pain Syndrome
Dr Rich Blake (podiatrist)
Saint Francis Memorial
Hospital, San Francisco, CA
I am treating many
patients right now with a diagnosis of Complex Regional Pain Syndrome. It is a gross understatement to say I am treating
them, since they can only be treated by a team of people since it is too
complex. The most important person on that team is the patient, and they really
call the shots, and hopefully I can help with direction and technical issues. If you are given that diagnosis, also known as Reflex
Sympathetic Dystrophy or RSD, you are scared. The doctors and
therapists who treat you are scared for you. The quicker the diagnosis is made and appropriate treatment is started, the better the response, but even those whose diagnosis is made at a snail's pace can get
better. I love to see these patients every 2 weeks since there is so much to do
and get organized. The visits should be a constant exploration and expansion of
these Mainstays of Treatment: Identifying the source of pain, completely
eliminating the pain cycle, nutrition, rehabilitation of limb function, being
as productive as possible, and handling co-morbidities of anxiety and depression.
I hope this summary does help those suffering make sure nothing is being
forgotten, and every visit to the managing doc is as productive as possible.
The Mainstays of
Treatment are:
·
Identifying Source of Pain
1.
MRI/CT Scans
2.
Bone Scan
3.
Diagnostic Injections (local or into the back)
4.
Nerve Conduction Studies
5.
Lab Tests
§
Sed Rate
§ CBC
§
Free T4 and TSH
§
Vit B12 and D3 Levels
§
HgbA1c
§
Morning Fasting Blood Sugars
·
Completely eliminating/breaking the Pain
Cycle
1.
Mechanical Means
§
Roll A Bout Scooter
§
AFO (Ankle Foot Orthotic)
§
Crutches
§
Tibia Wt Bearing Brace (Freedom
Brace or Zero G Types)
§
Activity Modification
§
Custom Made Orthotics to
stabilize an injured area (Hannaford based orthotic with memory
Foam best to start). Some
patients can take no arch pressure initially and need some
Version of taping to get
support.
§
Taping (Kinesiotape or Support
the Foot, but no complete enclosure)
2.
Oral Medications
§
Anti-Seizure (ie Lyrica)
§
Anti-Depressant (ie
Nortriptyline)
§
Others through Pain Management
Specialists
§ Low Dose Naltrexone (1-4.5 mg/day)
§
Sublingual Ketamine for flare-ups
3.
Topical Medications/ Applications (gels and
lotions best for ease of application)
§
Warm Compresses
§
Non Painful Massage
§
Parafin Wax (Target sells, but
heat must feel great)
§
Chinese Herbs
§
Lidoderm Patches (especially
for sleeping, can be above the sore area)
§
Neuro-Eze (OTC applied 3 times
daily—buy online)
§
50% DMSO cream 99.9% Pure
(mixed with other medicines as below)
§
Multiple Compounding
Medications which include (usually not all of these):
ü
Ketamine 10%
ü
Clonidine 0.2%
ü
Gabapentin 6%
ü Baclofen 2%
ü Nifedipine 2%
ü
Lidocaine 2%
4.
Alternative (only in category, very main stream for
this condition)
§ Biofeedback
(Thermal to increase circulation)
§
Hypnosis
§
Meditation (30 minutes to 1
hour per day)
§
Acupuncture (can be to opposite
limb or ear)
§
Graded Motor Imagery
(laterality flashcards and mirror therapy)
§
Somatic Experience technique
·
Nutritional (next 3-12 months)
1. Alpha Lipoic
Acid 300mg 2x/day
2.
Acety-L-Carnitine 2000 mg/day
3.
Inositol 500-1000mg/day
4. Vit B1 (5-30 mg/day)
5.
Vit B6 50mg/day
6.
Vit B12 1000mg/day
7. Vit E (up to
1,600units/day)
8. Vitamin C (500 mg/day for 45 days)
9. Vitamin D 3 (1000 units/day) --have blood level drawn and get to 45-50
level
10. Thyroid Natural Supplements
·
Rehabilitation of Limb Function
1.
Lower Extremities (keep strong as long as pain free)
Physical Therapist must be skilled in Neuropathic Pain treatment, not just
musculo-skeletal. There are times to
Honor Pain and times to Push through Pain, that can change from day to day.
2.
Core (support feet and legs from above with less
pressure on feet overall)
3.
Cardio (improve overall circulation and health)
4.
Whole Body (must address physical, emotional,
spiritual sides together)
5. Swimming in a Warm Water Pool is one of
the best forms of rehab out there for CRPS
6. Patient must learn how to avoid triggers
(sometimes cold drafts, loud noise, etc).
7. Patient must have thorough understanding
of the concept of neural tension and how to protect the sciatic nerve (or how
not to irritate).
8. Neural Gliding or Flossing 3 times a day
with Spine Neutral
·
Being as Productive as Possible (while nerves are healing) Can Help Nerves
Heal
1.
Part Time Work
2.
Volunteer
3.
Projects
·
Dealing with
CoMorbities of Anxiety and Depression
Possible Sources of
Information/Support/Inspiration
ü
American Chronic Pain Association
ü
American Academy of Pain Management
ü
Reflex Sympathetic Dystrophy Syndrome Association
ü
How To Cope With Pain blog
Psychological Workup/Treatment for Biofeedback/Depression/Anxiety
·
Other Important Treatment Options
1. As
the symptoms from the CRPS calms down, focus again may be necessary on the
original injury which could serve as a trigger for flares.
2. Sympathetic Blocks are crucial in the first
year, and their effectiveness wanes more and more as time goes on.
3. Consider Ketamine Infusion and Calmare Pain
Therapy (if there are centers in your area) over the more aggressive Spinal
Cord Stimulators. Both of these require initial 10 day commitments, but have
great potential.
4. Neuro Prolotherapy injections are a great help to patients.